Locus coeruleus lesions and learning

Locus coeruleus lesions and avoidance behavior in rats.

Bilateral electrolytic lesions of the locus coeruleus were performed in rats. In comparison with controls, lesioned rats showed decreased acquisition of two-way avoidance response, less intertrial responses, longer latency of avoidance responses on the first day of training, and needed more trials to reach the extinction criterion. It is suggested that locus coeruleus, contrary to the ventral n...

Learning, the P3, and the locus coeruleus-norepinephrine system

Locus coeruleus involvement in the learning of classically conditioned bradycardia.

Opioid agonists are known to inhibit the activity of locus coeruleus (LC) neurons. In this study, microinjections of the mu-opioid agonist [D-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin (DAMGO; 1.6 microM) bilaterally into the LC caused a significant impairment in the development of a heart-rate (HR) conditioned response (CR). The adverse effect of DAMGO on the HR CR could be reversed with naltrexone ...

Locus Coeruleus and Dopamine-Dependent Memory Consolidation

Most everyday memories including many episodic-like memories that we may form automatically in the hippocampus (HPC) are forgotten, while some of them are retained for a long time by a memory stabilization process, called initial memory consolidation. Specifically, the retention of everyday memory is enhanced, in humans and animals, when something novel happens shortly before or after the time ...

locus coeruleus lesions and pcos: role of the central and peripheral sympathetic nervous system in the ovarian function of rat

abstract background: “polycystic ovary syndrome (pcos) is a complex endocrine and metabolic disorder associated with ovulatory dysfunction”. “autonomic and central nervous systems play important roles in the regulation of ovarian physiology”. the noradrenergic nucleus locus coeruleus (lc) plays a central role in the regulation of the sympathetic nervous system and synaptically connected to the ...